MersV1, Main, Exploration, bibRecord, 000B84

Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.

Identifieur interne : 000B84 ( Main/Exploration ); précédent : 000B83; suivant : 000B85

Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.

Auteurs : Xiaoyan Lu [Géorgie (pays)] ; Lori A. Rowe [Géorgie (pays)] ; Michael Frace [Géorgie (pays)] ; James Stevens [Géorgie (pays)] ; Glen R. Abedi [Géorgie (pays)] ; Osman Elnile [Arabie saoudite] ; Taleb Banassir [Arabie saoudite] ; Malak Al-Masri [Arabie saoudite] ; John T. Watson [Géorgie (pays)] ; Abdullah Assiri [Arabie saoudite] ; Dean D. Erdman [Géorgie (pays)]

Source :

Journal of medical virology [ 1096-9071 ] ; 2017.

RBID : pubmed:27486688

Descripteurs français

KwdFr :
- Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Délétion de séquence, Flambées de maladies, Glycoprotéine de spicule des coronavirus (génétique), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Sérum (virologie), Variation génétique.
MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus, Sérum.
- épidémiologie : Arabie saoudite, Infections à coronavirus.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Délétion de séquence, Flambées de maladies, Humains, Variation génétique.

English descriptors

KwdEn :
- Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Disease Outbreaks, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Saudi Arabia (epidemiology), Sequence Deletion, Serum (virology), Spike Glycoprotein, Coronavirus (genetics).
MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- epidemiology : Coronavirus Infections, Saudi Arabia.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Serum.
- Disease Outbreaks, Genetic Variation, Humans, Sequence Deletion.

Abstract

The spike glycoprotein of the Middle East respiratory coronavirus (MERS-CoV) facilitates receptor binding and cell entry. During investigation of a multi-facility outbreak of MERS-CoV in Taif, Saudi Arabia, we identified a mixed population of wild-type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS-CoV present as a quasispecies. J. Med. Virol. 89:542-545, 2017. © 2016 Wiley Periodicals, Inc.

DOI: 10.1002/jmv.24652
PubMed: 27486688

Affiliations:

Arabie saoudite, Géorgie (pays)

Le document en format XML

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<term>Genetic Variation</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (classification)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
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<front><div type="abstract" xml:lang="en">The spike glycoprotein of the Middle East respiratory coronavirus (MERS-CoV) facilitates receptor binding and cell entry. During investigation of a multi-facility outbreak of MERS-CoV in Taif, Saudi Arabia, we identified a mixed population of wild-type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERS-CoV present as a quasispecies. J. Med. Virol. 89:542-545, 2017. © 2016 Wiley Periodicals, Inc.</div>
</front>
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Serveur d'exploration MERS

Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.

Spike gene deletion quasispecies in serum of patient with acute MERS-CoV infection.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.